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| Tuesday, September 30th , 2025 |
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| New Britain Rock Cats: Fired Pitching Coach Blake McGinley. |
| New Britain Rock Cats: Appointed Boone Logan as Pitching Coach. |
| Tuesday, September 16th , 2025 |
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| Harrisburg Senators: 3B Jesús Saldaña retired from professional baseball. |
| Binghamton Mets: RP Leo Hendricks retired from professional baseball. |
| Bowie Baysox: CL Jose Maita retired from professional baseball. |
| Altoona Curve: SP Jorge Gonzáles retired from professional baseball. |
| Binghamton Mets: RP Perkyn Rodriguez retired from professional baseball. |
| Bowie Baysox: SP Geoff Stewart retired from professional baseball. |
| Binghamton Mets: 2B Samuel Castro retired from professional baseball. |
| New Hampshire Fisher Cats: RP Dave Richmond retired from professional baseball. |
| Bowie Baysox: SP Ken Cooper retired from professional baseball. |
| Portland Sea Dogs: SP Henderson Alvarez retired from professional baseball. |
| Bowie Baysox: 1B Keon Barnum retired from professional baseball. |
| Bowie Baysox: 3B Antony Morillo retired from professional baseball. |
| Bowie Baysox: 2B Wilson Amador retired from professional baseball. |
| Reading Fightin Phils: 3B Oscar Cotes retired from professional baseball. |
| Binghamton Mets: CF Jean Carlos Arias retired from professional baseball. |
| Reading Fightin Phils: RP Giel Adriaens retired from professional baseball. |
| Akron RubberDucks: RP Tim Young retired from professional baseball. |
| Bowie Baysox: 2B Juan Durán retired from professional baseball. |
| Altoona Curve: CL Stan Martínez retired from professional baseball. |
| Bowie Baysox: SP Jerry Knight retired from professional baseball. |
| Binghamton Mets: LF Eric Morgan retired from professional baseball. |
| Altoona Curve: C Luis De Jesús retired from professional baseball. |
| New Britain Rock Cats: CF Sancho Vásquez retired from professional baseball. |
| Reading Fightin Phils: RP Bob Nelson retired from professional baseball. |
| Bowie Baysox: 2B Bernie Green retired from professional baseball. |
| Reading Fightin Phils: SP Alan Jenkins retired from professional baseball. |
| Binghamton Mets: CL Dave Hall retired from professional baseball. |
| Binghamton Mets: RP Quincy Todd retired from professional baseball. |
| Harrisburg Senators: SP Marc Ingram retired from professional baseball. |
| Bowie Baysox: RP Sam Foster retired from professional baseball. |
| Bowie Baysox: RP Max Arthur retired from professional baseball. |
| Erie SeaWolves: CF J.J. Cortini retired from professional baseball. |
| Bowie Baysox: RP Jon Smith retired from professional baseball. |
| Altoona Curve: RP Art Triska retired from professional baseball. |
| Reading Fightin Phils: 3B Johnathan Santos retired from professional baseball. |
| Portland Sea Dogs: SP Ken Wright retired from professional baseball. |
| Harrisburg Senators: RP Víctor Lara retired from professional baseball. |
| New Hampshire Fisher Cats: LF Don Morán retired from professional baseball. |
| Harrisburg Senators: SP Ken Adams retired from professional baseball. |
| Harrisburg Senators: SS Daniel Tisserand retired from professional baseball. |
| New Hampshire Fisher Cats: CL Greg Thomas retired from professional baseball. |
| Altoona Curve: CF Buddy Barnett retired from professional baseball. |
| Akron RubberDucks: Activated SS Esteban González from the injured list. |
| Akron RubberDucks: Activated 2B Mario Padilla from the injured list. |
| Akron RubberDucks: Released RP Jared Hall. |
| Akron RubberDucks: Released LF Anthony Garcia. |
| Reading Fightin Phils: Hitting Coach Franklin Stubbs retires. |
| New Britain Rock Cats: Placed CF Jorge García on the active roster. |
