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| Thursday, September 25th , 2025 |
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| Potomac Nationals: RP Don Cash retired from professional baseball. |
| Potomac Nationals: RP Leomar Pereda retired from professional baseball. |
| Potomac Nationals: C Luis Valéncia retired from professional baseball. |
| Frederick Keys: CF Dave McDaniel retired from professional baseball. |
| Frederick Keys: LF Alfredo González retired from professional baseball. |
| Carolina Mudcats: 2B Rhett Clark retired from professional baseball. |
| Frederick Keys: C Kel Goode retired from professional baseball. |
| Frederick Keys: 1B Edwin Hall retired from professional baseball. |
| Frederick Keys: LF Gjèrgji Thika retired from professional baseball. |
| Potomac Nationals: 2B Erik Foster retired from professional baseball. |
| Myrtle Beach Pelicans: RP Sergio López retired from professional baseball. |
| Frederick Keys: LF Mike Sandoval retired from professional baseball. |
| Winston-Salem Dash: RP Ed McDermott retired from professional baseball. |
| Potomac Nationals: RP Kurt Dawson retired from professional baseball. |
| Frederick Keys: RF Joe Blanton retired from professional baseball. |
| Potomac Nationals: C Jeff Wallace retired from professional baseball. |
| Winston-Salem Dash: SP Joaquín Hernández retired from professional baseball. |
| Lynchburg Hillcats: Activated RP Doug Shelton from the injured list. |
