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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Salazar, Leonardo | LF | Pulaski Yankees | 21 | 05/13/2004 | Santiago | DOM | Right | Right | 6' 5" | 200 lbs | - |
| Sampson, Johnny | CF | Bristol Pirates | 24 | 04/17/2001 | San Antonio | USA | Right | Right | 6' 1" | 200 lbs | - |
| Santana, Ron | CL | Bristol Pirates | 25 | 05/11/2000 | Fremont | USA | Right | Right | 6' 0" | 190 lbs | - |
| Sasser, Clint | LF | Johnson City Cardinals | 20 | 08/23/2005 | Zuni Pueblo | USA | Right | Right | 5' 9" | 165 lbs | - |
| Saunders, Greg | RP | Pulaski Yankees | 22 | 09/21/2003 | Sterling Heights | USA | Switch | Right | 6' 4" | 195 lbs | - |
| Sellers, Cam | SP | Burlington Royals | 23 | 02/28/2002 | New Orleans | USA | Left | Right | 6' 0" | 200 lbs | - |
| Sheffield, Jeff | RP | Kingsport Mets | 21 | 06/04/2004 | Cooper City | USA | Right | Left | 6' 5" | 185 lbs | - |
| Sizemore, Greg | C | Kingsport Mets | 21 | 01/31/2004 | Champlin | USA | Switch | Right | 6' 4" | 205 lbs | - |
| Smith, Dave | SP | Burlington Royals | 22 | 07/15/2003 | St. Paul | USA | Right | Right | 6' 2" | 185 lbs | - |
| Smith, Don | RF | Johnson City Cardinals | 24 | 07/06/2001 | Mansfield | USA | Right | Left | 5' 10" | 190 lbs | - |
| Smith, Kevin | CF | Elizabethton Twins | 23 | 11/29/2001 | Westwood | USA | Right | Right | 6' 4" | 200 lbs | - |
| Smith, Rex | RP | Pulaski Yankees | 21 | 08/08/2004 | Rome | USA | Right | Left | 6' 0" | 170 lbs | - |
| Sousa, Héctor | 1B | Danville Firebirds | 18 | 06/30/2007 | Maracaibo | VEN | Right | Right | 6' 3" | 200 lbs | - |
| Spencer, Don | LF | Kingsport Mets | 23 | 09/14/2002 | Garden City | USA | Left | Left | 6' 2" | 190 lbs | - |
| Steele, Dave | CF | Danville Firebirds | 23 | 11/10/2001 | Brooklyn | USA | Right | Right | 6' 2" | 185 lbs | - |
| Stehn, Gus | RP | Greeneville Astros | 20 | 09/18/2005 | Fountainbleau | USA | Right | Left | 6' 3" | 175 lbs | - |
| Suggs, Marlon | SP | Danville Firebirds | 20 | 05/14/2005 | Houston | USA | Right | Right | 6' 6" | 190 lbs | - |
| Sullivan, Jim | C | Johnson City Cardinals | 20 | 03/31/2005 | Reisterstown | USA | Right | Right | 6' 0" | 180 lbs | - |
| Swanson, Randy | 3B | Free Agent | 25 | 06/12/2000 | Highland City | USA | Switch | Right | 6' 2" | 200 lbs | - |
| Sánchez, José | C | Pulaski Yankees | 20 | 12/15/2004 | San Juan | PUR | Right | Right | 6' 2" | 200 lbs | - |
