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| Friday, September 26th , 2025 |
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| West Virginia Power: C José Venegas retired from professional baseball. |
| Savannah Sand Gnats: 2B José Morán retired from professional baseball. |
| Rome Firebirds: RP Ron Cochran retired from professional baseball. |
| Delmarva Shorebirds: C Mabarak Afridi retired from professional baseball. |
| Lakewood BlueClaws: 3B Ed Wheeler retired from professional baseball. |
| Delmarva Shorebirds: SP Jon Ayers retired from professional baseball. |
| Savannah Sand Gnats: RP Jerry Kahwagi retired from professional baseball. |
| West Virginia Power: RF Jeff Hutchinson retired from professional baseball. |
| Savannah Sand Gnats: 1B Pete Crawford retired from professional baseball. |
| Kannapolis Intimidators: RP Tim Browning retired from professional baseball. |
| Lakewood BlueClaws: C Glen Donahue retired from professional baseball. |
| Savannah Sand Gnats: CL Jonathan Kelly retired from professional baseball. |
| Savannah Sand Gnats: 2B Jim Hurst retired from professional baseball. |
| Asheville Tourists: 2B Jim MacKinney retired from professional baseball. |
| West Virginia Power: LF Juan López retired from professional baseball. |
| West Virginia Power: CF Jim Smith retired from professional baseball. |
| Lakewood BlueClaws: 1B Don Crouch retired from professional baseball. |
| Savannah Sand Gnats: SP Rubén Villanueva retired from professional baseball. |
| Asheville Tourists: Placed CF José Bustamante on the active roster. |
| Asheville Tourists: Activated CF José Bustamante from the injured list. |
