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| Friday, October 17th , 2025 |
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| Toronto (DSL) Blue Jays: Received SP Montrelle Bagio from the international complex. |
| Cleveland (DSL) Guardians: Received SP Luis Trujillo from the international complex. |
| Cleveland (DSL) Guardians: Received SP Cris Ortíz from the international complex. |
| Cleveland (DSL) Guardians: Received SP José Limón from the international complex. |
| Cleveland (DSL) Guardians: Received SP Bernardo Gonzáles from the international complex. |
| Cleveland (DSL) Guardians: Received SP Jorge Díaz from the international complex. |
| Cleveland (DSL) Guardians: Received 2B Luis Valéncia from the international complex. |
| Cleveland (DSL) Guardians: Received SP Gilberto Martínez from the international complex. |
| Cleveland (DSL) Guardians: Received SP Manny Morán from the international complex. |
| Cleveland (DSL) Guardians: Received SP Luis Álvarez from the international complex. |
| Cleveland (DSL) Guardians: Received SP Cristián Gallegos from the international complex. |
| Cleveland (DSL) Guardians: Received SP Sergio Pérez from the international complex. |
| Kansas City (DSL) Royals: Received SP Luis Costoya from the international complex. |
| Minnesota (DSL) Twins: Received SP Juan Vélez from the international complex. |
| Oakland (DSL) Athletics: Received SP Héctor López from the international complex. |
| Chicago N (DSL) Cubs: Received SP Luis Antonio García from the international complex. |
| Cleveland (DSL) Guardians: Released RP Chris McGuire. |
| Thursday, October 16th , 2025 |
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| Cincinnati (DSL) Rojos: Signed Manager Albert Pujols. |
| Saturday, September 27th , 2025 |
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| Minnesota (DSL) Twins: Activated SP Luis Muñóz from the injured list. |
| Wednesday, September 24th , 2025 |
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| Los Angeles (DSL) Angels: RP Andy Richter retired from professional baseball. |
| Philadelphia (DSL) Phillies: 3B Quentin Mobley retired from professional baseball. |
| Cincinnati (DSL) Reds: 3B Cliff Mosley retired from professional baseball. |
| New York N 2 (DSL) Mets 2: 1B Joe Griffith retired from professional baseball. |
| New York A 2 (DSL) Yankees 2: RP Joe Green retired from professional baseball. |
| San Francisco (DSL) Giants: RP Leon Gill retired from professional baseball. |
| Philadelphia (DSL) Phillies: 2B Monty White retired from professional baseball. |
| Texas (DSL) Rangers: RP Tim Butler retired from professional baseball. |
| Chicago A (DSL) White Sox: SS Ernie Herman retired from professional baseball. |
| Cincinnati (DSL) Rojos: RP Joe Buckner retired from professional baseball. |
| Texas 2 (DSL) Rangers 2: RF Luis Molina retired from professional baseball. |
| New York N (DSL) Mets 1: 3B Jim Walsh retired from professional baseball. |
| Baltimore (DSL) Orioles 2: 3B Jorge Pérez retired from professional baseball. |
| Arizona (DSL) Diamondbacks: RP Bob Morán retired from professional baseball. |
| Texas (DSL) Rangers: 1B Tameyoshi Murata retired from professional baseball. |
| San Francisco (DSL) Giants: RP Bob Walton retired from professional baseball. |
| Baltimore (DSL) Orioles 2: RP Chet Kirkpatrick retired from professional baseball. |
| Cleveland (DSL) Guardians: Activated CF Steve Cobb from the injured list. |
| San Diego (DSL) Padres: Activated 2B Orlando Ovalle from the injured list. |
| Chicago N (DSL) Cubs: Pitching Coach Jose Bautista retires. |
| Cincinnati (DSL) Rojos: Manager Joe Kmak retires. |
| Colorado (DSL) Rockies: Placed SP Lou Cates on the active roster. |
| Colorado (DSL) Rockies: Activated SP Lou Cates from the injured list. |
| Colorado (DSL) Rockies: Placed SS José Hernández on the active roster. |
| Colorado (DSL) Rockies: Activated SS José Hernández from the injured list. |
| Colorado (DSL) Rockies: Placed RP Ken Moss on the active roster. |
| Colorado (DSL) Rockies: Activated RP Ken Moss from the injured list. |
| Colorado (DSL) Rockies: Placed SP Iván Rodríguez on the active roster. |
| Colorado (DSL) Rockies: Activated SP Iván Rodríguez from the injured list. |
