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| Name | Pos | Team | Age | DOB | POB | Nationality | Bats | Throws | Height | Weight | Salary |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Saldaño, Juan | LF | Free Agent | 26 | 09/09/1999 | Levittown | PUR | Left | Left | 6' 2" | 200 lbs | - |
| Samurakami, Tadashi | RP | Albuquerque Isotopes | 36 | 04/30/1989 | Tokyo | JPN | Right | Right | 6' 1" | 195 lbs | $16,000,000 |
| Santiago, Mario | RF | Sacramento River Cats | 25 | 09/05/2000 | Santo Domingo | DOM | Right | Left | 6' 7" | 215 lbs | - |
| Sargent, Josh | 3B | Omaha Storm Chasers | 28 | 09/03/1997 | Larkspur | USA | Right | Right | 6' 2" | 200 lbs | - |
| Sargent, Tony | RP | Salt Lake Bees | 25 | 06/06/2000 | Haughton | USA | Left | Left | 6' 2" | 195 lbs | - |
| Saul, Mike | CF | Reno Aces | 25 | 12/23/2000 | Winter Garden | USA | Right | Right | 6' 2" | 200 lbs | - |
| Scallini, Galtero | 2B | El Paso Chihuahuas | 27 | 07/13/1998 | Naples | ITA | Right | Right | 6' 4" | 200 lbs | $750,000 |
| Schoop, Jonathan | 2B | Free Agent | 34 | 10/16/1991 | Unknown | ANT | Right | Right | 6' 2" | 205 lbs | - |
| Scott, Don | SP | Salt Lake Bees | 25 | 11/02/2000 | Perryton | USA | Right | Right | 6' 5" | 205 lbs | - |
| Serven, Hemerson | 3B | Round Rock Express | 28 | 11/11/1997 | Maracay | VEN | Switch | Right | 5' 11" | 215 lbs | - |
| Settignano, Beniamino | SP | Fresno Grizzlies | 22 | 05/14/2003 | Barcelona | VEN | Right | Right | 6' 2" | 180 lbs | - |
| Shane, Casey | SP | Memphis Redbirds | 30 | 08/23/1995 | Frisco | USA | Right | Right | 6' 3" | 195 lbs | - |
| Sherman, Eddie | RP | Sacramento River Cats | 25 | 09/03/2000 | Highlands Ranch | USA | Right | Right | 6' 0" | 190 lbs | - |
| Silva, Doug | SP | Free Agent | 28 | 01/30/1998 | Lancaster | USA | Left | Left | 6' 0" | 205 lbs | - |
| Skaggs, Tyler | SP | Free Agent | 34 | 07/13/1991 | Santa Monica | USA | Left | Left | 6' 4" | 205 lbs | - |
| Smith, Bob | SS | Round Rock Express | 26 | 03/02/2000 | Westminster | USA | Switch | Right | 6' 1" | 190 lbs | - |
| Smith, Elroy | SP | Oklahoma City Dodgers | 31 | 09/24/1994 | Clinton | USA | Right | Right | 6' 3" | 205 lbs | - |
| Smith, Mallex | LF | Omaha Storm Chasers | 32 | 05/06/1993 | Tallahassee | USA | Left | Right | 5' 9" | 200 lbs | - |
| Smith, Randy | SP | Colorado Springs Sky Sox | 24 | 09/16/2001 | Rockport | USA | Right | Right | 6' 4" | 200 lbs | - |
| Smyly, Drew | SP | Nashville Sounds | 36 | 06/13/1989 | Little Rock | USA | Left | Left | 6' 3" | 200 lbs | - |
| Snell, Blake | SP | Oklahoma City Dodgers | 33 | 12/04/1992 | Seattle | USA | Left | Left | 6' 4" | 195 lbs | - |
| Snow, Wes | 2B | Free Agent | 26 | 07/19/1999 | Oak Park | USA | Left | Right | 6' 2" | 205 lbs | - |
| Sosa, José | CF | Las Vegas 51s | 25 | 02/21/2001 | Cúa | VEN | Left | Left | 6' 2" | 195 lbs | - |
| Spencer, Stan | SP | Omaha Storm Chasers | 26 | 09/25/1999 | Columbus | USA | Right | Right | 6' 2" | 200 lbs | - |
| Stallings, Jacob | C | Free Agent | 36 | 12/22/1989 | Brentwood | USA | Right | Right | 6' 5" | 225 lbs | - |
| Stevenson, Tim | CF | Albuquerque Isotopes | 24 | 09/06/2001 | Perry Hall | USA | Right | Right | 6' 1" | 185 lbs | - |
| Stevenson, Tristan | RP | Albuquerque Isotopes | 26 | 04/09/1999 | Tulsa | USA | Right | Right | 6' 6" | 210 lbs | - |
| Stewart, Alan | CF | Albuquerque Isotopes | 28 | 05/24/1997 | Harrisburg | USA | Switch | Right | 6' 1" | 200 lbs | - |
| Stewart, Eddie | RP | Colorado Springs Sky Sox | 26 | 12/23/1999 | Redondo Beach | USA | Right | Right | 6' 0" | 195 lbs | - |
| Strong, Stan | 2B | Las Vegas 51s | 25 | 01/01/2001 | Lower Burrell | USA | Right | Right | 6' 0" | 185 lbs | - |
| Sullivan, Ron | RP | Free Agent | 35 | 12/01/1990 | Denton | USA | Right | Right | 6' 2" | 210 lbs | - |
| Svela, Milo | RP | Reno Aces | 26 | 03/11/2000 | Laurence Harbor | USA | Left | Left | 6' 2" | 200 lbs | - |
| Sánchez, Orlando | CF | Albuquerque Isotopes | 24 | 03/02/2002 | Carolina | PUR | Left | Left | 5' 10" | 185 lbs | - |
| Sánchez, Tomás | SP | Nashville Sounds | 24 | 09/22/2001 | Santo Domingo | DOM | Right | Right | 6' 2" | 190 lbs | - |
